Diagnostic research priorities at the IVI in Bern and Mittelhäusern include the use of modern sequencing methods (metagenomics, virome screening) for early detection of emerging viruses and determination of viral diversity, e.g. in wild animals, as well as the suitability of alternative, non-invasive sample materials for epizootic surveillance. In the latter context, the IVI is involved, e.g., in the project "Constanze 2 - Active surveillance of avian influenza in wild birds at Lake Constance". The aim of this EFSA-funded research project of the countries bordering Lake Constance is to investigate whether swab samples from the vicinity of waterfowl colonies are suitable for surveillance of avian influenza.